November 27, 2006Archives of Internal Medicine
Prediction of Coronary Artery Calcium in Young Adults Using the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Risk Score
Key result
A 1-point increase in the PDAY risk score significantly increased the odds of having any coronary artery calcium 15 years later (OR 1.09 to 1.15), with c statistics ranging from 0.752 to 0.770.
Why the study?
Does the PDAY risk score predict the presence and amount of coronary artery calcium in young adults?
Population
Young adults participating in the 15-year examination of the Coronary Artery Risk Development in Young…
Design
Cohort
Follow-up
15 years
Authors
Discussion
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Implication
PDAY score in young adults predicts later CAC; extends autopsy data but remains hypothesis-generating pending prospective trials.
Study Design
Type
Cohort
Structured PICO
Does the PDAY risk score predict the presence and amount of coronary artery calcium in young adults?
P
Population
Young adults participating in the 15-year examination of the Coronary Artery Risk Development in Young Adults (CARDIA) study
I
Intervention
Pathobiological Determinants of Atherosclerosis in Youth (PDAY) risk score (based on age, sex, smoking status, HDL and non-HDL cholesterol, obesity, hyperglycemia, and hypertension)
O
Outcome
Amount and presence of coronary artery calcium (CAC) assessed by computed tomography at year 15surrogate
Main Result
Effect estimate: OR 1.09-1.16
The PDAY risk score, calculated from modifiable risk factors in young adulthood, effectively predicts the presence of coronary artery calcium up to 15 years later.
Cite This Study
Samuel S. Gidding (2006) conducted a cohort in Coronary Artery Calcium. PDAY risk score was evaluated on Amount and presence of coronary artery calcium (CAC) (OR 1.09-1.16). A 1-point increase in the PDAY risk score significantly increased the odds of having any coronary artery calcium 15 years later (OR 1.09 to 1.15), with c statistics ranging from 0.752 to 0.770.