Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Risk Score in Young Adults Predicts Coronary Artery and Abdominal Aorta Calcium in Middle Age
Key result
Baseline PDAY risk scores in young adulthood more strongly predicted coronary artery calcium 25 years later than concurrent scores (OR 1.29; 95% CI 1.25-1.33 vs OR 1.12; 95% CI 1.11-1.14).
Why the study?
Does the PDAY risk score measured in young adulthood better predict coronary and abdominal aortic calcium 25 years later compared to scores measured concurrently?
Population
3008 participants aged 18 to 30 years from the Coronary Artery Risk Development in Young Adults (CARDIA) study
Comparison
Pathobiological Determinants of Atherosclerosis… vs PDAY scores measured 25 years later
Design
Cohort
Follow-up
25 years
Authors
Discussion
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Implication
Early PDAY scores may better stratify long-term CAC risk than concurrent measures; extends observational evidence on cumulative exposure but requires validation.
Study Design
Type
Cohort (n=3,008)
Structured PICO
Does the PDAY risk score measured in young adulthood better predict coronary and abdominal aortic calcium 25 years later compared to scores measured concurrently?
P
Population
3008 participants aged 18 to 30 years from the Coronary Artery Risk Development in Young Adults (CARDIA) study
I
Intervention
Pathobiological Determinants of Atherosclerosis in Youth (PDAY) coronary and abdominal risk scores measured at baseline (18 to 30 years of age)
C
Comparator
PDAY scores measured 25 years later
O
Outcome
Presence and extent of coronary artery calcium (CAC) and abdominal aortic calcium (AAC) assessed 25 years later (at 43 to 55 years of age)surrogate
Main Result
Effect estimate: OR 1.29 (95% CI 1.25-1.33)
Atherosclerosis risk assessed in young adulthood provides strong prediction of future subclinical atherosclerosis, highlighting the importance of early risk exposure.
Cite This Study
Gidding et al. (2015) conducted a cohort in Subclinical atherosclerosis (n=3,008). Baseline PDAY risk score (years 0) vs. Year 25 PDAY risk score was evaluated on Presence of coronary artery calcium (CAC) per 1-point higher score (OR 1.29, 95% CI 1.25-1.33). Baseline PDAY risk scores in young adulthood more strongly predicted coronary artery calcium 25 years later than concurrent scores (OR 1.29; 95% CI 1.25-1.33 vs OR 1.12; 95% CI 1.11-1.14).