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December 24, 2018IDCasesOpen Access

Salmonella enterica serovar Typhi osteomyelitis in a young adult with sickle cell and thalassemia traits: A possible association

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Authors

SSStephanie StephanieSSSarah Schmalzle

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Overview

Case report reports chronic Salmonella Typhi femoral osteomyelitis in an adult with sickle cell and thalassemia traits, suggesting milder hemoglobinopathies elevate bacterial bone infection risk.

Key Points

  • Evaluate the clinical presentation and potential association between minor hemoglobinopathies and chronic Salmonella enterica serovar Typhi osteomyelitis.
  • Clinical and microbiological evaluation of a Maryland resident presenting with chronic femoral osteomyelitis after traveling to a Salmonella-endemic area.
  • Hematologic diagnostic assessment identifying newly diagnosed, concurrent sickle cell trait and thalassemia trait.
  • Salmonella enterica serovar Typhi was isolated from a chronic femoral bone infection in a patient lacking classic immunocompromising conditions.
  • Concurrent sickle cell trait and thalassemia trait, combined with endemic travel, served as the primary identified risk factors for severe bone infection.

Cite This Study

Stephanie et al. (2018) studied this question.

synapsesocial.com/papers/6a12ac54ea48cb855a354aa6https://doi.org/10.1016/j.idcr.2018.e00478
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Salmonella Typhi Osteomyelitis of the Ulnar Diaphysis in an Immunocompetent Adult: A Case Report2026
  2. 2Musculoskeletal infections caused by <i>Salmonella Typhi</i> : A series of two case reports in immunocompetent adults2026
  3. 3Septic Arthritis due to 2025
  4. 4Osteomyelitis in Sickle Cell Anemia: Does Age Predict Risk of Salmonella Infection?2023 · 12 citations
  5. 5Non-Typhoidal Salmonella enterica Bacteremia Complicated by Native Shoulder Septic Arthritis in a Patient with Sickle Cell Disease Following Foodborne Exposure: A Case Report and Literature Review2026