Key result
Prolonged sinus QRS duration in idiopathic PVCs is linked to ~30% higher odds of symptoms.
Why the study?
Premature ventricular complexes are common arrhythmias that can lead to dilated cardiomyopathy or ventricular tachycardia, motivating an evaluation of the relationship between QRS duration and symptoms in idiopathic PVC.
Cross-Sectional (n=242)
Yes
Effect estimate: OR 1.3 (95% CI 1.01-1.05)
Absolute Event Rate: 89% vs 80%
p-value: p=0.002
Prolonged sinus QRS duration is significantly associated with the presence of symptoms in patients with idiopathic premature ventricular complexes.
May flag symptomatic idiopathic PVC patients; hypothesis-generating and requires prospective validation before clinical use.
Aim: Premature ventricular complexes are one of the most common arrhythmias and, when not treated, can cause serious complications such as dilated cardiomyopathy and ventricular tachycardia. In our study, we investigated the relationship between QRS duration and symptoms in patients with idiopathic premature ventricles complex (IPVC). Material and Methods: This is a multicenter, cross-sectional study involving 242 consecutive patients with more than 1,000 idiopathic PVC and normal QRS duration in 24-hour Holter follow-up who attended cardiology clinics in 18 different centers between January 2019 and May 2019. The relationship between the QRS durations was investigated by dividing the patients into 2 groups as symptomatic (n: 128) and asymptomatic (n: 114). Result: The average age of 242 patients was 51 ± 13 and 52.4% (127) of them were male patients. In the symptomatic IPVC group, sinus QRS duration, PVC QRS duration, coupling interval, and prematurity index were statistically significantly higher than the asymptomatic IPVC group. In the multivariate logistic regression analysis, a significant relationship was found between the sinus QRS duration (odds ratio (OR) = 1.3, 95% confidence interval (CI) = 1.01-1.05, p = 0.002) and symptoms in patients with IPVC. In the ROC analysis performed to show the power of sinus QRS duration in predicting symptoms in patients with IPVC, Area Under Curve (AUC) value was found as = 0.547 95% CI: 0.454-0.640, p = 0.320 (Figure 1). Conclusion: In patients with IPVC; The prolonged sinüs QRS duration was found to be superior to other parameters in patients being symptomatic.
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Akın et al. (2021) conducted a cross-sectional in Idiopathic premature ventricular complex (IPVC) (n=242). Symptomatic IPVC vs. Asymptomatic IPVC was evaluated on Sinus QRS duration (ms) (OR 1.3, 95% CI 1.01-1.05, p=0.002). In patients with idiopathic premature ventricular complexes, prolonged sinus QRS duration was significantly associated with the presence of symptoms (OR 1.3).
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