September 3, 2002Circulation
Importance of Cardiac Troponins I and T in Risk Stratification of Patients With Acute Pulmonary Embolism
Key result
Elevated cardiac troponin in acute pulmonary embolism is linked to increased mortality and complications.
- P=0.019
- n=106
Why the study?
Assessment of risk and appropriate management of patients with acute pulmonary embolism remains a challenge, and the role of cardiac troponins I and T in risk stratification requires clarification.
Does elevation of cardiac troponins I and T predict mortality and complicated in-hospital course in patients with acute pulmonary embolism?
Population
106 consecutive patients with confirmed acute pulmonary embolism
Comparison
Patients with elevated cardiac troponins I and T vs patients with normal or moderately elevated levels
Design
Prospective observational study
Follow-up
In-hospital
Authors
Discussion
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Implication
Troponin elevation was associated with higher mortality in acute PE; supports prognostic use but leaves open therapeutic implications.
Study Design
Type
Observational (n=106)
Structured PICO
Does elevation of cardiac troponins I and T predict mortality and complicated in-hospital course in patients with acute pulmonary embolism?
P
Population
106 consecutive patients with confirmed acute pulmonary embolism (PE)
I
Intervention
Measurement of cardiac troponins I (cTnI) and T (cTnT) for risk stratification
C
Comparator
Patients with normal or moderately elevated troponin levels
O
Outcome
Overall mortality and complicated in-hospital coursehard clinical
Main Result
p-value: P=0.019
High levels of cardiac troponins I and T are strong predictors of in-hospital mortality and complicated clinical course in patients with acute pulmonary embolism.
Cite This Study
Konstantinides et al. (2002) conducted an observational in Acute pulmonary embolism (n=106). Cardiac troponins I and T assessment vs. Normal or moderately elevated troponin levels was evaluated on Overall mortality and complicated in-hospital course (p=P=0.019). High levels of cardiac troponin I (>1.5 ng/mL) or T (>0.1 ng/mL) in acute pulmonary embolism significantly increased mortality risk (P=0.019 and P=0.038, respectively) and in-hospital complications.