What is the clinical evidence from this study?

Study design: Observational. Population: Suspected pulmonary embolism (n=106). Intervention: Pulmonary embolism vs. No pulmonary embolism. Primary outcome: High cardiac troponin I (cTnI) levels (p=<0.001).

What does this research mean for the field?

Elevated cardiac troponin I levels occur in approximately half of patients with confirmed pulmonary embolism compared to 11.6% without PE, providing high diagnostic specificity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the diagnostic utility of serum cardiac troponin I (cTnI) levels and examine their association with electrocardiography (ECG) and transthoracic echocardiography (TTE) findings in suspected pulmonary embolism (PE).

December 1, 2012Open Access

Significance of serum cardiac troponin I levels in pulmonary embolism.

Q: What are the key findings of this study?

High cardiac troponin I levels were present in 50.8% of patients with confirmed pulmonary embolism compared to 11.6% of patients without pulmonary embolism (P<0.001).

Q: What does this research mean for the field?

Elevated cardiac troponin I levels occur in approximately half of patients with confirmed pulmonary embolism compared to 11.6% without PE, providing high diagnostic specificity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To evaluate the diagnostic utility of serum cardiac troponin I (cTnI) levels and examine their association with electrocardiography (ECG) and transthoracic echocardiography (TTE) findings in suspected pulmonary embolism (PE).

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Key result

Elevated cTnI occurs ~4-fold more frequently in confirmed PE versus non-PE patients.

P<0.001
n=106

Why the study?

Some biomarkers can aid in diagnosing pulmonary embolism and determining its severity and prognosis, but the role of cardiac troponin I levels in this context requires analysis.

Does elevated serum cardiac troponin I (cTnI) aid in the diagnosis of pulmonary embolism in patients with suspected PE?

Population

106 patients with suspected pulmonary embolism

Comparison

Elevated cardiac troponin I levels vs normal levels in patients with and without PE

Design

Observational study

Authors

GKGonca Kilinc ÖDÖmer Tamer DoğanVascular Medicine SBSerdar BerkSivas Cumhuriyet Üniversitesi

Discussion

Member takes

Implication

Elevated cTnI was associated with ECG/TTE changes in PE; leaves open added prognostic value beyond standard risk scores.

Key Points

To evaluate the diagnostic utility of serum cardiac troponin I (cTnI) levels and examine their association with electrocardiography (ECG) and transthoracic echocardiography (TTE) findings in suspected pulmonary embolism (PE).
Enrolled 106 patients presenting with suspected PE, confirming diagnosis in 63 patients and excluding it in 43 patients.
Measured baseline serum cTnI levels prior to the initiation of anticoagulation therapy alongside ECG and TTE assessments.
Elevated cTnI levels were present in 50.8% of patients with confirmed PE compared to 11.6% without PE (P<0.001), demonstrating 50.7% sensitivity and 88.3% specificity.
Approximately 75% of PE patients with high cTnI had normal ECGs, with the S1Q3T3 pattern being the most common abnormality (~31%), showing no significant ECG variation by troponin status.
Pulmonary hypertension occurred in ~74% of PE patients with elevated cTnI, though TTE findings did not differ significantly between patients with normal versus elevated cTnI levels.

Study Design

Type

Observational (n=106)

Structured PICO

Does elevated serum cardiac troponin I (cTnI) aid in the diagnosis of pulmonary embolism in patients with suspected PE?

Population

106 patients with suspected pulmonary embolism evaluated for the diagnostic value of cardiac troponin I levels.

Exposure

Measurement of serum cardiac troponin I (cTnI) levels

Comparator

Normal cTnI levels / patients without PE

Outcome

Diagnosis of pulmonary embolism and association with ECG and TTE findingssurrogate

Main Result

Absolute Event Rate: 50.8% vs 11.6%

p-value: p=<0.001

Elevated serum cardiac troponin I levels have high specificity but low sensitivity for diagnosing pulmonary embolism and may indicate severe PE.

Cite This Study

Kilinc et al. (2012) conducted an observational in Suspected pulmonary embolism (n=106). Pulmonary embolism vs. No pulmonary embolism was evaluated on High cardiac troponin I (cTnI) levels (p=<0.001). High cardiac troponin I levels were present in 50.8% of patients with confirmed pulmonary embolism compared to 11.6% of patients without pulmonary embolism (P<0.001).

synapsesocial.com/papers/6ab387192e40ce78267983ef https://doi.org/10.3978/j.issn.2072-1439.2012.10.13

Topics

Pulmonary embolism

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Significance of serum cardiac troponin I levels in pulmonary embolism.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Significance of serum cardiac troponin I levels in pulmonary embolism.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider