Key result
Admission cTnT differentiates intermediate from low-risk PE and correlates with severity after six hours.
Why the study?
The appropriate timing of cardiac troponin T measurement for early triage of pulmonary embolism patients was not established.
Does the timing of cardiac troponin T measurement correlate with disease severity for early triage in patients with pulmonary embolism?
Cohort (n=104)
No
Does the timing of cardiac troponin T measurement correlate with disease severity for early triage in patients with pulmonary embolism?
Measurement of cardiac troponin T on admission can effectively differentiate intermediate from low-risk patients with pulmonary embolism, aiding in early triage.
Answers are grounded in this paper and cite their sources.
Admission troponin T may aid early PE risk stratification; leaves open optimal timing and needs prospective validation.
AIM: To determine the appropriate timing of cardiac troponin T (cTnT) measurement for the early triage of pulmonary embolism (PE) patients. METHODS: In this single-center prospective study, PE was confirmed in all patients using computed tomography. 104 consecutive patients were divided into three groups (high-risk, intermediate, and low-risk) based on their hemodynamic status and echocardiographic signs of right ventricular dysfunction. cTnT levels were measured on admission and then after 6, 24, 48, and 72 hours with threshold values greater than 0.1 ng/mL. RESULTS: Intermediate-risk PE patients had higher cTnT levels than low-risk patients already in the first measurement (P=0.037). Elevated cTnT levels significantly correlated with disease severity after 6 hours (intermediate vs low risk patients, P=0.016, all three groups, P=0.009). CONCLUSION: In hemodynamically stable patients, increased cTnT level on admission differentiated intermediate from low-risk patients and could be used as an important element for the appropriate triage of patients.
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Bulj et al. (2013) conducted a cohort in Pulmonary embolism (n=104). Cardiac troponin T (cTnT) measurement vs. Low-risk pulmonary embolism patients was evaluated on Difference in cTnT levels between intermediate and low-risk patients on admission (p=0.037). Cardiac troponin T measurement on admission differentiated intermediate-risk from low-risk pulmonary embolism patients (P=0.037), and correlated with disease severity after 6 hours (P=0.009).
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