Key result
Reverse cardio-oncology reveals that pre-existing cardiovascular conditions and shared risk factors, such as inflammation and clonal hematopoiesis, significantly increase the likelihood of cancer development.
Why the study?
Cardio-oncology has traditionally focused on cancer therapy effects on cardiovascular health, but the emerging field of reverse cardio-oncology shifts perspective to examine how cardiovascular diseases influence cancer onset and progression.
This review highlights the emerging field of reverse cardio-oncology, emphasizing that cardiovascular diseases and their associated systemic alterations can actively promote oncogenesis and cancer progression.
Cardiovascular disease (CVD) and cancer are leading causes of mortality worldwide, traditionally linked through adverse effects of cancer therapies on cardiovascular health. However, reverse cardio-oncology, a burgeoning field, shifts this perspective to examine how cardiovascular diseases influence the onset and progression of cancer. This novel approach has revealed a higher likelihood of cancer development in patients with pre-existing cardiovascular conditions, attributed to shared risk factors such as obesity, a sedentary lifestyle, and smoking. Underlying mechanisms like chronic inflammation and clonal hematopoiesis further illuminate the connections between cardiovascular ailments and cancer. This comprehensive narrative review, spanning a broad spectrum of studies, outlines the syndromic classification of cardio-oncology, the intersection of cardiovascular risk factors and oncogenesis, and the bidirectional dynamics between CVD and cancer. Additionally, the review also discusses the pathophysiological mechanisms underpinning this interconnection, examining the roles of cardiokines, genetic factors, and the effects of cardiovascular therapies and biomarkers in cancer diagnostics. Lastly, it aims to underline future directives, emphasising the need for integrated healthcare strategies, interdisciplinary research, and comprehensive treatment protocols.
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Imran et al. (2024) conducted a review in Cardiovascular disease and cancer (Reverse cardio-oncology). Reverse cardio-oncology reveals that pre-existing cardiovascular conditions and shared risk factors, such as inflammation and clonal hematopoiesis, significantly increase the likelihood of cancer development.
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