Key result
Cardiovascular disease promotes cancer incidence and progression by creating a systemic pro-tumorigenic milieu.
Why the study?
Recent studies suggest cardiovascular disease can lead to an increased risk of cancer and worse outcomes, pointing to a more complicated bidirectional CVD-cancer relationship.
Does the presence or development of cardiovascular disease accelerate cancer incidence and progression?
Does the presence or development of cardiovascular disease accelerate cancer incidence and progression?
Highlights the concept of 'reverse cardio-oncology', emphasizing that cardiovascular disease not only shares risk factors with cancer but actively drives a pro-tumorigenic systemic environment.
Answers are grounded in this paper and cite their sources.
May prompt cancer vigilance in CVD patients; leaves open causal confirmation and clinical adoption pending prospective trials.
The field of cardio-oncology has emerged in response to the increased risk of cardiovascular disease (CVD) in patients with cancer. However, recent studies suggest a more complicated CVD-cancer relationship, wherein development of CVD, either prior to or following a cancer diagnosis, can also lead to increased risk of cancer and worse outcomes for patients. In this review, we describe the current evidence base, across epidemiological as well as preclinical studies, which supports the emerging concept of 'reverse-cardio oncology', or CVD-induced acceleration of cancer pathogenesis.
No takes yet. Share an insight, caveat, or question.
Koelwyn et al. (2021) conducted a review in Cardiovascular disease and cancer. Cardiovascular disease vs. Absence of cardiovascular disease was evaluated. Epidemiological and preclinical evidence suggests a bidirectional relationship where cardiovascular disease promotes a systemic pro-tumorigenic milieu that accelerates cancer pathogenesis.
Synapse has enriched 10 related papers. Consider them for comparative context: