A breath-holding test after deep inspiration showed a significant inverse correlation with the single-breath carbon dioxide test (r=-0.82, p<0.05) for assessing peripheral chemoreflex sensitivity.
Observational (n=48)
Does a breath-holding test accurately reflect peripheral chemoreflex sensitivity compared to the single-breath carbon dioxide test in healthy subjects?
The breath-holding test is a feasible and reproducible method for assessing peripheral chemoreflex sensitivity, correlating well with the standard single-breath carbon dioxide test in healthy subjects.
Effect estimate: r=-0.82
p-value: p=<0.05
The aim of the study was to determine the feasibility of using a breath-holding test in assessing the sensitivity of the peripheral chemoreflex compared with the single-breath carbon dioxide test. The study involved 48 healthy volunteers between the ages of 18-29 years. The breath-holding test was performed followed by the single-breath carbon dioxide test on the next day. A month after the first tests, these tests were repeated to evaluate their reproducibility The coefficient of variability in the single-breath carbon dioxide test ranged from 0 to 32% with a mean of 10±7%. The mean coefficient of variability of the breath-holding test was 6±4% (0-19%). A significant inverse correlation between the results of the two tests was noted following analysis (r=-0.82, p<0.05). CONCLUSION: A breath-holding test after deep inspiration reflects the sensitivity of the peripheral chemoreflex as defined by the single-breath carbon dioxide test in healthy subjects.
Трембач et al. (Tue,) conducted a observational in Healthy subjects (n=48). Breath-holding test vs. Single-breath carbon dioxide test was evaluated on Correlation between breath-holding test and single-breath carbon dioxide test results (r=-0.82, p=<0.05). A breath-holding test after deep inspiration showed a significant inverse correlation with the single-breath carbon dioxide test (r=-0.82, p<0.05) for assessing peripheral chemoreflex sensitivity.