Key result
Obesity in healthy men was associated with a significantly lower duration of voluntary breath-holding (40.6 vs 47.2 seconds; P<.05), while peripheral chemoreflex sensitivity to CO2 was preserved.
Why the study?
Does obesity alter peripheral chemoreflex sensitivity to CO2 and breath-holding duration in healthy men?
Cross-Sectional (n=49)
Does obesity alter peripheral chemoreflex sensitivity to CO2 and breath-holding duration in healthy men?
In healthy men, obesity is associated with reduced voluntary breath-holding duration, which is linked to waist-to-hip ratio and peripheral chemoreflex sensitivity to CO2, despite preserved overall chemoreflex sensitivity.
Answers are grounded in this paper and cite their sources.
Peripheral chemoreflex CO2 sensitivity appears preserved in healthy obesity; leaves open mechanisms underlying shorter breath-holding.
The present study aimed to explore the peripheral chemoreflex sensitivity in healthy subjects with high body mass index (BMI). We studied 26 healthy men with obesity and 23 healthy men without obesity. All participants performed the breath-holding test in the morning, and the single-breath carbon dioxide (SB-CO2) test on the next day. The sensitivity of peripheral chemoreceptors to CO2 did not differ between two groups (P = .47). In contrast, the duration of breath-holding was significantly lower in participants with elevated BMI (40.6 ± 10.5 s versus 47.2 ± 8.7 s; P < .05). In the multifactor regression model, only differences in waist-to-hip ratio (WHR) and SB-CO2 remained statistically significant (R2 for the model = 0.62, P < .001). The sensitivity of peripheral chemoreflex to CO2 was preserved in healthy men with obesity. The higher sensitivity of peripheral chemoreflex to CO2 and higher WHR were associated with a decrease in the duration of voluntary apnea in subjects with obesity.
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Трембач et al. (2017) conducted a cross-sectional in Obesity (n=49). Obesity (high BMI) vs. Healthy men without obesity was evaluated on Duration of breath-holding (p=<.05). Obesity in healthy men was associated with a significantly lower duration of voluntary breath-holding (40.6 vs 47.2 seconds; P<.05), while peripheral chemoreflex sensitivity to CO2 was preserved.
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