June 1, 1975ThoraxOpen Access

Evaluation of breath holding in hypercapnia as a simple clinical test of respiratory chemosensitivity.

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Why the study?

Does breath holding in hypercapnia provide a useful index of respiratory chemosensitivity that is independent of airways obstruction?

Structured PICO

Does breath holding in hypercapnia provide a useful index of respiratory chemosensitivity that is independent of airways obstruction?

Population

38 subjects total: 16 healthy control subjects, 5 cases of idiopathic hypoventilation syndrome, and 17 patients with chronic airways obstruction.

Intervention

Breath holding test begun at selected degrees of hypercapnia produced by CO2 rebreathing.

Comparator

Comparison between healthy controls, patients with idiopathic hypoventilation syndrome, and patients with chronic airways obstruction.

Outcome

Breath-holding time (BHT) and the slope of a log BHT/Pco2 plot, and their correlation with ventilatory response to CO2.surrogate

The relationship between breath-holding time and PCO2 provides a useful index of respiratory chemosensitivity that is not confounded by coexisting airways obstruction.

Discussion

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Implication

BHT/PCO2 slope may index chemosensitivity independent of obstruction; supports hypothesis but leaves prospective validation open.

Cite This Study

Stanley et al. (1975) studied this question.

synapsesocial.com/papers/6a20369045d96add4db5d06c https://doi.org/10.1136/thx.30.3.337

View Full Paper

Ask AI

Bookmark

Evaluation of breath holding in hypercapnia as a simple clinical test of respiratory chemosensitivity.

Structured PICO

Discussion

Implication

Cite This Study

Evaluation of breath holding in hypercapnia as a simple clinical test of respiratory chemosensitivity.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider