What does this research mean for the field?

Beta-adrenergic stimulation enhances force-frequency-induced myocardial contractile responses in a dose-dependent manner in conscious dogs. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1992CirculationOpen Access

Enhancement of the force-frequency effect on myocardial contractility by adrenergic stimulation in conscious dogs.

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Why the study?

Does beta-adrenergic stimulation with dobutamine enhance the force-frequency effect on myocardial contractility in conscious dogs?

Population

7 instrumented conscious dogs in which heart rate could be controlled by atrial pacing after the intrinsic…

Comparison

Dobutamine infusion at low, intermediate, and… vs Resting conditions with progressive heart rate…

Design

Preclinical

Authors

MKMasashi KambayashiUniversity of California San Diego Medical Center TMTetsuji MiuraHeart Failure / Cardiomyopathy BOByung‐Hee OhHeart Failure & Transplant

Discussion

Member takes

Implication

Enhances force-frequency responses dose-dependently in conscious dogs; leaves open translation to human HF or clinical practice.

Structured PICO

Does beta-adrenergic stimulation with dobutamine enhance the force-frequency effect on myocardial contractility in conscious dogs?

Population

7 instrumented conscious dogs in which heart rate could be controlled by atrial pacing after the intrinsic rate was slowed with a bradycardiac agent (UL-FS 49 0.5-0.75 mg/kg)

Intervention

Dobutamine infusion at low, intermediate, and high doses (2.7, 5.4, and 10.7 micrograms/kg/min) with progressive heart rate increase from 100 to 210 beats per minute

Comparator

Resting conditions (absence of dobutamine) with progressive heart rate increase from 100 to 210 beats per minute

Outcome

Force-frequency effects on myocardial contraction (LV dP/dtmax) and relaxation (time constant of LV pressure fall, tau)surrogate

Beta-adrenergic stimulation with dobutamine produces a pronounced dose-dependent enhancement of force-frequency-induced contractile responses in normal conscious dogs.

Cite This Study

Kambayashi et al. (1992) studied this question.

synapsesocial.com/papers/6a12d154c031bb6829a75b5c https://doi.org/10.1161/01.cir.86.2.572

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Enhancement of the force-frequency effect on myocardial contractility by adrenergic stimulation in conscious dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Enhancement of the force-frequency effect on myocardial contractility by adrenergic stimulation in conscious dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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