Influence of acute alterations in heart rate and systemic arterial pressure on echocardiographic measures of left ventricular perfornmance in normal human subjects.
Why the study?
Do acute alterations in heart rate and systemic arterial pressure affect echocardiographic measures of left ventricular performance in normal human subjects?
Population
25 normal human subjects between the ages of 21 and 29 years.
Comparison
Intravenous atropine followed by phenylephrine… vs Baseline measurements prior to drug…
Follow-up
Acute (during drug administration)
Authors
Discussion
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Implication
Acute HR/BP changes alter Vcf; leaves open whether adjustments are needed for serial echo LV assessments.
Structured PICO
Do acute alterations in heart rate and systemic arterial pressure affect echocardiographic measures of left ventricular performance in normal human subjects?
P
Population
25 normal human subjects between the ages of 21 and 29 years.
I
Intervention
Intravenous atropine followed by phenylephrine infusion.
C
Comparator
Baseline measurements prior to drug administration.
O
Outcome
Mean velocity of left ventricular circumferential fiber shortening (Vcf) and mean posterior wall velocity (Vpw).surrogate
Echocardiographic measures of left ventricular performance (Vcf and Vpw) are highly sensitive to acute changes in heart rate and systemic arterial pressure, which must be accounted for during serial assessments.
Cite This Study
Hirshleifer et al. (1975) studied this question.