Key result
Heart failure patients with exercise intolerance exhibited rapid exercise-induced declines in skeletal muscle high-energy phosphates and reduced oxidative capacity compared with healthy controls.
Population
Patients with heart failure with reduced ejection fraction, patients with heart failure with preserved…
Comparison
Energetic plantar flexion exercise fatigability… vs Healthy controls and low-fatigability HFrEF…
Design
Cross-sectional
Authors
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Muscle metabolic deficits may contribute to HF exercise intolerance; hypothesis-generating and requires prospective trials before clinical consideration.
Observational
Heart failure patients with exercise intolerance demonstrate rapid exercise-induced declines in skeletal muscle high-energy phosphates, suggesting peripheral metabolic abnormalities contribute to fatigability.
Weiss et al. (2017) conducted an observational in Heart failure (HFrEF and HFpEF). Plantar flexion exercise fatigability test and magnetic resonance spectroscopy vs. Healthy controls was evaluated on Skeletal muscle high-energy phosphate concentrations and ATP flux rates. Heart failure patients with exercise intolerance exhibited rapid exercise-induced declines in skeletal muscle high-energy phosphates and reduced oxidative capacity compared with healthy controls.
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