Key result
Sympathetic reinnervation in heart-transplant recipients was associated with longer exercise time (8.2 vs 6.1 minutes; P<0.01) and higher peak heart rate (143 vs 121 bpm; P<0.01) than denervation.
Why the study?
Does sympathetic reinnervation improve cardiac performance and exercise capacity in heart transplant recipients?
Population
29 cardiac-transplant recipients and 10 healthy controls
Comparison
Sympathetic reinnervation vs Denervation
Design
Cohort
Authors
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Should not yet alter post-transplant care; hypothesis-generating for reinnervation-targeted interventions.
Observational (n=39)
Does sympathetic reinnervation improve cardiac performance and exercise capacity in heart transplant recipients?
Absolute Event Rate: 8.2% vs 6.1%
p-value: p=<0.01
Restoration of sympathetic innervation in heart-transplant recipients is associated with improved heart rate response and contractile function during exercise.
Bengel et al. (2001) conducted an observational in Cardiac transplantation (n=39). Sympathetic reinnervation vs. Denervation was evaluated on Exercise time (minutes) (p=<0.01). Sympathetic reinnervation in heart-transplant recipients was associated with longer exercise time (8.2 vs 6.1 minutes; P<0.01) and higher peak heart rate (143 vs 121 bpm; P<0.01) than denervation.
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