Key result
Systolic and diastolic hypertension (SDH) conferred the highest risk of stroke compared to normotensives (HR 2.96; 95% CI 2.49-3.52), with a particularly strong effect on hemorrhagic stroke.
Why the study?
Do different subtypes of hypertension increase the risk of stroke in middle-aged and older Chinese adults?
Population
26,587 subjects ≥35 years of age and free of stroke, recruited in 5 cities in China in 1987
Comparison
Subtypes of hypertension vs Normotensives
Design
Cohort
Follow-up
233,437 person-years total
Authors
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Supports subtype-specific stroke risk assessment; leaves open treatment implications in middle-aged Chinese adults.
Cohort (n=26,587)
Yes
Do different subtypes of hypertension increase the risk of stroke in middle-aged and older Chinese adults?
Effect estimate: HR 2.96 (95% CI 2.49-3.52)
Systolic and diastolic hypertension (SDH) confers the highest risk of stroke among hypertension subtypes in middle-aged and older Chinese adults, warranting aggressive treatment.
Fang et al. (2005) conducted a cohort in Hypertension (n=26,587). Hypertension subtypes (ISH, IDH, SDH, MHT) vs. Normotensives was evaluated on All stroke (HR 2.96, 95% CI 2.49-3.52). Systolic and diastolic hypertension (SDH) conferred the highest risk of stroke compared to normotensives (HR 2.96; 95% CI 2.49-3.52), with a particularly strong effect on hemorrhagic stroke.
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