Key result
Increases in left ventricular systolic volume (P<0.0001) and end-systolic area (P<0.0001), but not long axis, strongly predicted cardiac morbidity following an acute myocardial infarction.
Why the study?
Do changes in left ventricular area and geometry predict cardiac morbidity better than changes in long axis in post-myocardial infarction patients?
Cohort (n=756)
Do changes in left ventricular area and geometry predict cardiac morbidity better than changes in long axis in post-myocardial infarction patients?
Effect estimate: Chi-square 18.5
p-value: p=<0.0001
Changes in left ventricular area and geometry, rather than long axis measurements alone, are the primary predictors of cardiac morbidity following myocardial infarction.
May refine post-MI risk stratification with LV volume and area; hypothesis-generating for geometry over long-axis measures.
AIMS: Two-dimensional (2D) echocardiography has been widely applied to measure left ventricular volumes with the biplane Simpson's method in the assessment of left ventricular remodelling following an acute myocardial infarction. This volume formula is based upon tracings of endocardium and measurement of long axis on left ventricular images. In the present follow-up study of post-myocardial infarction patients we evaluated the prognostic impact of changes in left ventricular areas and geometry versus long axis to determine if only long-axis measurements may be used for prognostic purposes. METHODS AND RESULTS: Two-dimensional echocardiographic video recordings of the apical four-chamber and long-axis views were obtained in 756 patients 2--7 days and 3 months following an acute myocardial infarction. All videotapes were sent to a core laboratory and left ventricular volumes were measured with the biplane Simpson's method in end-diastole and end-systole. During the first 3 months 44 patients had suffered one of the following end-points and were excluded: cardiac death, recurrent myocardial infarction, heart failure or chronic arrhythmia. Over a period of 3--24 months 58 such end-points occurred. With the Cox proportional hazards model the increase in left ventricular systolic volume was the strongest predictor for such events (Chi-square 18.5, P<0.0001), followed by an increase in end-systolic area (Chi-square 17.0, P<0.0001) and end-systolic spherity index (Chi-square 8.74,P =0.003). The increase in end-systolic long axis had only a borderline predictive value (Chi-square 4.3, P=0.04). The change in long-axis shortening from end-diastole to end-systole had no significant predictive value at all. CONCLUSION: In the studied population changes in left ventricular area and geometry, but not in the long axis, were mainly related to cardiac morbidity. The proper assessment of changes in left ventricular dimensions should therefore be based upon tracings of the area and not on long axis measurements only.
No takes yet. Share an insight, caveat, or question.
Jan-Erik Otterstad (2001) conducted a cohort in Acute myocardial infarction (n=756). Echocardiographic measurement of left ventricular volume changes was evaluated on Cardiac death, recurrent myocardial infarction, heart failure or chronic arrhythmia (Chi-square 18.5, p=<0.0001). Increases in left ventricular systolic volume (P<0.0001) and end-systolic area (P<0.0001), but not long axis, strongly predicted cardiac morbidity following an acute myocardial infarction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: