Key result
Upgrading RVP to CRT, HBP, or LBBP improves LVEF in PICM.
Why the study?
Heart failure may appear with chronic right ventricle pacing as pacing-induced cardiomyopathy, but there is no internationally accepted definition for its diagnosis.
Does upgrading to physiological pacing (CRT, HBP, LBBP) improve outcomes in patients with pacing-induced cardiomyopathy compared to right ventricular pacing?
Does upgrading to physiological pacing (CRT, HBP, LBBP) improve outcomes in patients with pacing-induced cardiomyopathy compared to right ventricular pacing?
This review summarizes the diagnostic criteria, risk factors, and management strategies for pacing-induced cardiomyopathy, highlighting the emerging roles of His bundle and left bundle branch pacing as alternatives to biventricular pacing.
May support upgrade consideration in pacing-induced cardiomyopathy; leaves open confirmation by randomized trials.
Permanent pacemaker is the mainstay treatment indicated for bradycardia caused by sinus node dysfunction. However, heart failure may appear in patients with chronic right ventricle pacing, this is known as Pacing-Induced Cardiomyopathy (PICM). There is no internationally accepted definition for diagnosis of PICM. Studies show the prevalence of PICM is 9% in the first year and increases in proportion to the duration of PPM implantation, but varies widely according to diagnostic criteria used. PICM causes a higher all-cause death, hospital admission, and cardiac death. Therefore, detecting risk factors may be an important part of the prevention and early treatment of PICM. Once PICM develops, several therapy options are available but Cardiac Resynchronization Therapy with biventricular Pacemaker is currently the forefront of treatment. But insight into other more novel therapeutic options such as; His bundle pacing and Left Bundle Branch Pacing shows promising results as an alternative treatment option in the near future.
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Laksono et al. (2023) conducted a review in Pacing-Induced Cardiomyopathy (PICM). Cardiac Resynchronization Therapy (CRT), His Bundle Pacing (HBP), Left Bundle Branch Pacing (LBBP) vs. Right ventricular pacing was evaluated. Upgrading from right ventricular pacing to cardiac resynchronization therapy, His bundle pacing, or left bundle branch pacing improves left ventricular function in pacing-induced cardiomyopathy.
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