Prenatal X-Ray Exposure and Childhood Cancer23

Brian MacMahon

doi:10.1093/jnci/28.5.1173

May 1, 1962JNCI Journal of the National Cancer Institute

Prenatal X-Ray Exposure and Childhood Cancer23

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Key Points

Evaluate the association between in utero exposure to diagnostic maternal x-rays and the subsequent risk of developing childhood cancer and leukemia.
Conducted a large-scale retrospective review linking hospital birth registers with regional cancer and mortality records.
Assessed intrauterine radiographic examinations among mothers delivering at participating maternity centers and tracked subsequent cancer diagnoses in offspring.
Observed a statistically significant excess of childhood cancer deaths among children with documented prenatal x-ray exposure.
Identified an approximate 40% increase in the relative risk of childhood malignancies, including leukemia and central nervous system tumors, following diagnostic fetal radiation exposure.

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Implication

Epidemiological analysis demonstrates elevated cancer mortality following in utero x-ray exposure in pediatric cohorts, suggesting critical fetal vulnerability to ionizing radiation.

Abstract

Journal Article Prenatal X-Ray Exposure and Childhood Cancer Get access Brian MacMahon, M.D. Brian MacMahon, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 28, Issue 5, May 1962, Pages 1173–1191, https://doi.org/10.1093/jnci/28.5.1173 Published: 01 May 1962 Article history Received: 03 January 1962 Published: 01 May 1962

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Brian MacMahon (1962) studied this question.

synapsesocial.com/papers/6a130f9fd61942a939c092de https://doi.org/10.1093/jnci/28.5.1173

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Prenatal X-Ray Exposure and Childhood Cancer23

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Prenatal X-Ray Exposure and Childhood Cancer23

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