Key result
Baseline P-wave duration >100 ms was associated with a higher risk of AF-related hospitalizations compared to ≤100 ms (16.4% vs 10.4%; OR 1.6, 95% CI 1.1-2.8, P=0.044).
Why the study?
Does baseline P-wave duration > 100 ms predict AF-related hospitalizations in patients paced for bradycardia with associated AF?
Observational (n=660)
Does baseline P-wave duration > 100 ms predict AF-related hospitalizations in patients paced for bradycardia with associated AF?
A baseline P-wave duration >100 ms is associated with a higher risk of AF-related hospitalizations and need for cardioversion in patients with pacemakers for bradycardia and a history of AF.
Answers are grounded in this paper and cite their sources.
May aid AF risk stratification in paced bradycardia patients; leaves open prospective validation before practice change.
BACKGROUND: Atrial fibrillation (AF) is a common problem in pacemaker patients. We conducted a prospective observational study in patients paced for bradycardia with associated paroxysmal or persistent AF, to determine whether P-wave duration may stratify patients at higher risk for AF recurrences and AF-related hospitalizations. The patients were evaluated for the prevalence, cause, and predictors of hospitalization. METHODS: We studied 660 consecutive patients (50% male, 72 +/- 9 years) who received a dual-chamber pacemaker. Median value of baseline P-wave duration was equal to 100 ms (25%-75% quartile range equal to 80-120 ms). We used this cut-off to divide the patients into group A (P < or = 100 ms), composed of 385 (58.3%) patients, and group B (P>100 ms), composed of 275 (41.7%) patients. RESULTS: In a median follow-up of 19 months, 173 patients were hospitalized for all causes, 130 for cardiovascular causes, and 85 for AF-related hospitalizations. Multivariate logistic analysis showed that P-wave duration >100 ms identified patients at higher risk (OR = 1.6, 95% confidence interval (1.1-2.8), P = 0.044) for AF-related hospitalizations. Patients in group B (P > 100 ms) more frequently suffered AF-related hospitalizations (16.4% vs 10.4%, P = 0.02) and underwent more frequent cardioversions (14.5% vs 9.1%, P = 0.029) compared with group A (P < or = 100 ms). CONCLUSIONS: P-wave duration may define the risk of persistent AF requiring cardioversion or AF-related hospitalization in patients with a pacemaker for bradycardia with associated paroxysmal or persistent AF.
No takes yet. Share an insight, caveat, or question.
Padeletti et al. (2007) conducted an observational in Atrial fibrillation in patients paced for bradycardia (n=660). P-wave duration > 100 ms vs. P-wave duration ≤ 100 ms was evaluated on AF-related hospitalizations (OR 1.6, 95% CI 1.1-2.8, p=0.044). Baseline P-wave duration >100 ms was associated with a higher risk of AF-related hospitalizations compared to ≤100 ms (16.4% vs 10.4%; OR 1.6, 95% CI 1.1-2.8, P=0.044).
Synapse has enriched 10 related papers. Consider them for comparative context: