What does this research mean for the field?

Prolonged relaxation and diastolic dysfunction in post-myocardial infarction remodeled myocardium are partly caused by decreased basal phosphorylation of phospholamban, driven by increased protein phosphatase 1 activity. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 29, 1999Circulation Research

Diminished Basal Phosphorylation Level of Phospholamban in the Postinfarction Remodeled Rat Ventricle

View Full Paper

Ask AI

Bookmark

Population

Rat model 3 weeks after myocardial infarction with remodeled hypertrophy of noninfarcted myocardium and…

Comparison

Molecular and functional analysis of the… vs Control/sham myocytes

Design

Preclinical

Follow-up

3 weeks

Authors

BHBoyu HuangZhejiang University of Technology SWSu WangShantou Central Hospital DQDayi QinState University of New York

Discussion

Member takes

Implication

Increased PP1 activity may prolong relaxation post-MI; leaves open whether phosphatase inhibition improves diastolic function in patients.

Structured PICO

Population

Rat model 3 weeks after myocardial infarction with remodeled hypertrophy of noninfarcted myocardium and compensated stage (no evidence of heart failure)

Intervention

Molecular and functional analysis of the beta-adrenergic receptor pathway, sarcoplasmic reticulum Ca(2+)-ATPase, and phospholamban (PLB), including pharmacological probing with okadaic acid, Ro-20-1724, and pertussis toxin

Comparator

Control/sham myocytes

Outcome

Basal phosphorylation levels of phospholamban (p16-PLB and p17-PLB) and phosphatase activitysurrogate

Prolonged relaxation in post-MI remodeled myocardium is partly explained by decreased basal phosphorylation of phospholamban due to increased protein phosphatase 1 activity.

Cite This Study

Huang et al. (1999) studied this question.

synapsesocial.com/papers/6a135f8071369867e4937d81 https://doi.org/10.1161/01.res.85.9.848

View Full Paper

Ask AI

Bookmark

Implication

Increased PP1 activity may prolong relaxation post-MI; leaves open whether phosphatase inhibition improves diastolic function in patients.

Diminished Basal Phosphorylation Level of Phospholamban in the Postinfarction Remodeled Rat Ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Diminished Basal Phosphorylation Level of Phospholamban in the Postinfarction Remodeled Rat Ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider