What question did this study set out to answer?

To evaluate the electrophysiological characteristics, conduction velocities, and localized conduction delays within the canine right bundle branch under pacing and physical stress.

April 1, 1976CirculationOpen Access

Dissociation and delayed conduction in the canine right bundle branch.

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Why the study?

Does premature stimulation and mechanical pressure produce conduction delays and dissociation in the canine right bundle branch?

Population

Ten mongrel dogs

Comparison

Premature stimulation and mechanical pressure to… vs Normal sinus rhythm and unstressed right…

Design

Preclinical

Authors

AWAbe WalstonWalmart (United States)JBJohn P. BoineauElectrophysiology JAJames A. AlexanderSouthwest Research Institute

Discussion

Member takes

Implication

May simulate re-entrant arrhythmias via bundle dissociation; hypothesis-generating for human conduction mechanisms.

Key Points

To evaluate the electrophysiological characteristics, conduction velocities, and localized conduction delays within the canine right bundle branch under pacing and physical stress.
Recorded bipolar electrograms from 5 to 6 sites along the septal right bundle branch using a multielectrode patch in 10 mongrel dogs.
Assessed antegrade conduction during sinus rhythm and right atrial pacing, and retrograde conduction during right ventricular epicardial pacing.
Induced localized conduction delays using premature electrical stimulation and mechanical compression along the right bundle branch.
Conduction velocities averaged 2.0 m/sec (range 1.4 to 3.3 m/sec) during antegrade conduction and 2.1 m/sec (range 1.8 to 2.7 m/sec) during retrograde activation.
Conduction delays occurred across discrete segments with normal propagation velocity regenerating distal to the area of block.
Conduction delays caused electrogram fragmentation and generated delayed antegrade and retrograde activation waves consistent with longitudinal dissociation.

Structured PICO

Does premature stimulation and mechanical pressure produce conduction delays and dissociation in the canine right bundle branch?

Population

Ten mongrel dogs

Intervention

Premature stimulation and mechanical pressure to the right bundle branch

Comparator

Normal sinus rhythm and unstressed right atrial/ventricular pacing

Outcome

Conduction velocities and conduction delays in the right bundle branchsurrogate

Stress-induced longitudinal dissociation in the right bundle branch can produce delayed activation waves that may simulate re-entrant arrhythmias.

Cite This Study

Walston et al. (1976) studied this question.

synapsesocial.com/papers/6a136e731e0f24f0db16cc94 https://doi.org/10.1161/01.cir.53.4.605

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Dissociation and delayed conduction in the canine right bundle branch.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Dissociation and delayed conduction in the canine right bundle branch.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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