Key result
Early aspirin post-CABG shows no association with increased 24-hour drainage output.
Why the study?
Guidelines recommend early aspirin loading within 6 h of CABG to improve vein graft patency, but this is not standard practice due to bleeding concerns.
Does early aspirin administration (300 mg within 6 hours) increase bleeding risk in patients post-CABG?
Observational (n=160)
No
Does early aspirin administration (300 mg within 6 hours) increase bleeding risk in patients post-CABG?
Absolute Event Rate: 695.7% vs 712.7%
p-value: p=0.777
Early administration of 300 mg aspirin within 6 hours post-CABG does not increase bleeding risk or associated complications, supporting current guideline recommendations.
Early aspirin post-CABG was not linked to increased drainage; leaves open need for randomized confirmation of safety.
BACKGROUND: Guidelines recommend early aspirin loading (150-325 mg) within 6 h of coronary artery bypass grafting (CABG), which improves patency of vein grafts. Due to bleeding concerns, this is not standard practice. AIMS: The aim of this study is to review early aspirin administration, within 6 h of CABG, to determine if there is an increased risk of bleeding. METHODS: Bleeding risk was evaluated in 160 patients, undergoing CABG procedure from January 2022 to February 2023. Patients were divided into two groups: those that received 300 mg of aspirin within 6 h (group 1) and those that did not (group 2). Drainage output from different timepoints, red cell, platelet transfusion rates, pericardial effusion, and re-exploration for bleeding were reviewed. Statistical analysis was performed using STATA/BE version 18.0. Significance was demonstrated when p value < 0.05. RESULTS: Mean output drainage at 24 h was 695.7 mL for group 1 and 712.7 mL for group 2. Considering 11 timepoints, there were no significant difference between groups (p values = 0.731-0.117). Transfusion rates for red cells (p = 0.734) and platelets (p = 0.274), re-exploration for bleeding (p = 0.694), and pericardial effusion rates (p = 0.472) also showed no statistical difference. CONCLUSIONS: A comprehensive review of drainage output, red cell, platelet transfusion, re-exploration for bleeding, and pericardial effusion rates was performed, post early aspirin administration. Aspirin (300 mg) given within 6 h of CABG surgery did not lead to increased bleeding and associated complications.
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Staunton et al. (2025) conducted an observational in Coronary artery bypass grafting (CABG) (n=160). Early aspirin vs. No early aspirin was evaluated on Mean output drainage at 24 hours (mL) (p=0.777). Aspirin (300 mg) given within 6 hours of CABG surgery did not significantly increase mean 24-hour drainage output compared to no early aspirin.
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