Key result
Digoxin lacks definitive data to clarify the range of serum concentrations associated with clinical benefit, as the traditional 0.8-2.0 ng/ml range was originally developed to classify toxicity.
Why the study?
What is the optimal therapeutic range of serum digoxin concentrations for clinical efficacy in patients with heart failure?
Population
Patients with left ventricular dysfunction and normal sinus rhythm
Design
Review
Authors
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Questions reliance on traditional digoxin targets in HF; leaves open efficacy-linked concentrations for prospective trials.
What is the optimal therapeutic range of serum digoxin concentrations for clinical efficacy in patients with heart failure?
The traditional therapeutic range of digoxin (0.8-2.0 ng/ml) reflects toxicity thresholds rather than efficacy, indicating a gap in evidence for optimal dosing in heart failure.
Terra et al. (1999) conducted a review in Heart failure with left ventricular dysfunction and normal sinus rhythm. Digoxin was evaluated. Digoxin lacks definitive data to clarify the range of serum concentrations associated with clinical benefit, as the traditional 0.8-2.0 ng/ml range was originally developed to classify toxicity.
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