What is the clinical evidence from this study?

Study design: Observational. Population: Dilated cardiomyopathy (n=98). Intervention: Electrocardiography and echocardiography vs. Normal subjects. Primary outcome: Apparent electromechanical delay (ms) (p=< 0.01).

What does this research mean for the field?

Dilated cardiomyopathy is associated with symmetrically delayed mechanical systole in both ventricles, indicating bilateral bundle branch block, and a significantly reduced apparent electromechanical delay. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate ventricular activation characteristics and their relationship with mechanical events in dilated cardiomyopathy patients.

August 1, 1994HeartOpen Access

Nature of ventricular activation in patients with dilated cardiomyopathy: evidence for bilateral bundle branch block.

Q: What are the key findings of this study?

Dilated cardiomyopathy was associated with symmetrically delayed mechanical systole compatible with bilateral bundle branch block and reduced apparent electromechanical delay (43 vs 75 ms, P<0.01).

Q: What does this research mean for the field?

Dilated cardiomyopathy is associated with symmetrically delayed mechanical systole in both ventricles, indicating bilateral bundle branch block, and a significantly reduced apparent electromechanical delay. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To investigate ventricular activation characteristics and their relationship with mechanical events in dilated cardiomyopathy patients.

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Key result

Dilated cardiomyopathy was associated with symmetrically delayed mechanical systole compatible with bilateral bundle branch block and reduced apparent electromechanical delay (43 vs 75 ms, P<0.01).

Population

77 patients with dilated cardiomyopathy, 6 patients with a normal sized left ventricle and complete right…

Design

Cohort

Authors

HXH B XiaoShenzhen Metro (China)CRCraig RoyRoyal Brompton Hospital DGD G GibsonCardiac Imaging

Discussion

Member takes

Implication

May indicate bilateral bundle branch block in DCM with LBBB; hypothesis-generating and should not yet alter CRT selection.

Key Points

To investigate ventricular activation characteristics and their relationship with mechanical events in dilated cardiomyopathy patients.
Analyzed 12 lead electrocardiograms and signal averaged electrocardiograms.
Utilized M mode and Doppler echocardiograms to assess mechanical functions.
Included 77 dilated cardiomyopathy patients and 15 normal controls.
QRS duration in dilated cardiomyopathy patients was significantly longer (127 ms vs 90 ms, P < 0.05).
Early potential duration was longer in patients (30 ms) compared to controls (12 ms, P < 0.01).
Mechanical systole onset was symmetrically delayed in both ventricles in patients, indicating bilateral bundle branch block.

Study Design

Type

Observational (n=98)

Multicenter

Structured PICO

Population

77 patients with dilated cardiomyopathy (mean age 59±13, 4 after aortic valve replacement, 3 after coronary bypass surgery), 6 patients with a normal sized left ventricle and complete right bundle branch block, and 15 normal subjects (mean age 45±20) as controls.

Comparator

Normal subjects (controls)

Outcome

Nature of ventricular activation and its relation with mechanical events measured by 12-lead ECG, signal-averaged ECG, and M-mode/Doppler echocardiographysurrogate

Main Result

Absolute Event Rate: 43% vs 75%

p-value: p=< 0.01

In patients with dilated cardiomyopathy and an ECG pattern of LBBB or intraventricular block, mechanical systole is symmetrically delayed in both ventricles, suggesting bilateral bundle branch block with activation via the upper septum.

Cite This Study

Xiao et al. (1994) conducted an observational in Dilated cardiomyopathy (n=98). Electrocardiography and echocardiography vs. Normal subjects was evaluated on Apparent electromechanical delay (ms) (p=< 0.01). Dilated cardiomyopathy was associated with symmetrically delayed mechanical systole compatible with bilateral bundle branch block and reduced apparent electromechanical delay (43 vs 75 ms, P<0.01).

synapsesocial.com/papers/6a13dc7ef88db7183c5981fb https://doi.org/10.1136/hrt.72.2.167

Topics

Echocardiography

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Nature of ventricular activation in patients with dilated cardiomyopathy: evidence for bilateral bundle branch block.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Nature of ventricular activation in patients with dilated cardiomyopathy: evidence for bilateral bundle branch block.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider