Key result
Heart rate reduction by either ivabradine or metoprolol significantly increased cardiac angiogenesis in post-MI rats, with capillary to myocyte ratio correlating to heart rate (r = -0.324, P=0.036).
Why the study?
Does heart rate reduction with ivabradine or metoprolol improve cardiac angiogenesis and endothelial dysfunction in a rat model of post-MI heart failure?
Population
Rat model of post-myocardial infarction (MI) heart failure
Comparison
Ivabradine or metoprolol initiated early or late… vs Untreated MI rats and sham-operated rats
Design
Preclinical
Follow-up
12 weeks
Authors
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No immediate clinical implications; hypothesis-generating for heart rate reduction promoting post-MI angiogenesis in humans.
Does heart rate reduction with ivabradine or metoprolol improve cardiac angiogenesis and endothelial dysfunction in a rat model of post-MI heart failure?
Effect estimate: r = -0.324
p-value: p=0.036
In a rat model of post-MI heart failure, heart rate reduction with ivabradine or metoprolol increases cardiac angiogenesis regardless of the timing of therapy onset, but largely fails to prevent endothelial dysfunction.
Ulu et al. (2009) studied Post-MI heart failure. Ivabradine or metoprolol vs. Untreated MI and sham animals was evaluated on Capillary to myocyte ratio and endothelial function (r = -0.324, p=0.036). Heart rate reduction by either ivabradine or metoprolol significantly increased cardiac angiogenesis in post-MI rats, with capillary to myocyte ratio correlating to heart rate (r = -0.324, P=0.036).
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