Key result
Metoprolol treatment from 7 or 17 weeks of age significantly improved survival at 21 weeks (86% and 75%, respectively, vs 25% in untreated controls) in rats with diastolic heart failure.
Why the study?
Does metoprolol improve survival and left ventricular function in hypertensive rats with diastolic heart failure?
Population
Dahl salt-sensitive hypertensive rats fed a high-salt diet from 7 weeks of age (n=50)
Comparison
Metoprolol treatment starting from 7 weeks of… vs No treatment (n=20)
Design
Preclinical, randomized
Follow-up
up to 21 weeks of age
Authors
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Metoprolol improves survival in this rat diastolic HF model; hypothesis-generating and leaves open human translation.
RCT (n=50)
randomized
Does metoprolol improve survival and left ventricular function in hypertensive rats with diastolic heart failure?
Absolute Event Rate: 86% vs 25%
Metoprolol improved survival and prevented the progression of diastolic dysfunction in a rat model of hypertensive diastolic heart failure.
Kobayashi et al. (2004) conducted an RCT in diastolic heart failure (n=50). metoprolol vs. no treatment was evaluated on Survival at 21 weeks of age. Metoprolol treatment from 7 or 17 weeks of age significantly improved survival at 21 weeks (86% and 75%, respectively, vs 25% in untreated controls) in rats with diastolic heart failure.
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