Why the study?
Does chemical sympathectomy, beta-blockade, or alpha-blockade improve survival in rats with pressure overload left ventricular hypertrophy?
Does chemical sympathectomy, beta-blockade, or alpha-blockade improve survival in rats with pressure overload left ventricular hypertrophy?
In a rat model of pressure overload left ventricular hypertrophy, alpha-adrenoceptor blockade and chemical sympathectomy, but not beta-blockade, significantly improved survival and diastolic dysfunction.
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Alpha-blockade and sympathectomy merit translational study over beta-blockade in pressure-overload LVH; leaves open human applicability.
Perlini et al. (2006) studied this question.
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