Key result
ACE inhibitors have potentially salutary effects in acute and chronic ischaemia by reducing preload, afterload, and free radical damage, warranting further exploration.
Why the study?
Do ACE inhibitors provide benefit in acute and chronic ischemia?
Do ACE inhibitors provide benefit in acute and chronic ischemia?
ACE inhibitors have potential benefits in acute and chronic ischemia through hemodynamic improvements and possible free radical reduction.
Answers are grounded in this paper and cite their sources.
May support ACE inhibitor consideration in ischemia; leaves open need for prospective trials before practice change.
Myocyte loss, reactive hypertrophy, dynamic ischaemia with 'stunning', and ventricular wall remodelling are all involved in the initiation and progression of myocardial failure which is ischaemic in origin. 2. The effects of ACE inhibitors to reduce preload and afterload has potentially salutary effects in these settings. Moreover, sulphyl containing ACE inhibitors may have further actions in reducing free radicals and their damage in the acute phases of these events. 3. These promising initial studies warrant further exploration.
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Sonnenblick et al. (1989) conducted a review in Acute and chronic ischaemia. ACE inhibitors was evaluated. ACE inhibitors have potentially salutary effects in acute and chronic ischaemia by reducing preload, afterload, and free radical damage, warranting further exploration.
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