Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1989British Journal of Clinical PharmacologyOpen Access

Relationships between structure and effects of ACE inhibitors: comparative effects in myocardial ischaemic/reperfusion injury.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Do sulfhydryl-containing ACE inhibitors reduce myocardial ischemia/reperfusion injury in experimental models?

Population

Experimental models of coronary occlusion followed by reperfusion (myocardial ischemia/reperfusion injury)

Comparison

Sulfhydryl-containing ACE inhibitors vs Non-sulfhydryl ACE inhibitors or control

Design

Review

Authors

KPKarin PrzyklenkCross-Cutting CardiologyRKRA KlonerGood Samaritan Hospital

Discussion

Loading...

Member takes

Implication

May support dual ACE inhibition plus radical scavenging in experimental reperfusion injury; leaves open clinical translation.

Structured PICO

Do sulfhydryl-containing ACE inhibitors reduce myocardial ischemia/reperfusion injury in experimental models?

P
Population
Experimental models of coronary occlusion followed by reperfusion (myocardial ischemia/reperfusion injury)
I
Intervention
Sulfhydryl-containing ACE inhibitors (e.g., captopril)
C
Comparator
Non-sulfhydryl ACE inhibitors (e.g., enalapril) or control
O
Outcome
Indices of myocardial injury (infarct size, creatine kinase release) and contractile function of stunned myocardiumsurrogate

Sulfhydryl-containing ACE inhibitors like captopril may provide dual benefits in myocardial ischemia/reperfusion injury by both inhibiting ACE and scavenging cytotoxic free radicals.

Cite This Study

Przyklenk et al. (1989) studied this question.

synapsesocial.com/papers/6a85405e3cde6ee03eb2ea3bhttps://doi.org/10.1111/j.1365-2125.1989.tb03592.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Functional improvement of jeopardized myocardium following intracoronary streptokinase infusion in acute myocardial infarction.1983 · 229 citations
  2. 2Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia.1985 · 323 citations
  3. 3The stunned myocardium: prolonged, postischemic ventricular dysfunction.1982 · 2,816 citations
  4. 4Absence of a cumulative deterioration of regional function during three repeated 5 or 15 minute coronary occlusions.1984 · 94 citations
  5. 5Failure of superoxide dismutase to limit size of myocardial infarction after 40 minutes of ischemia and 4 days of reperfusion in dogs.1987 · 197 citations