Why the study?
Does ACE inhibitor administration reduce ET-1 secretion and reperfusion arrhythmias in perfused rat hearts?
Population
Perfused rat hearts undergoing 60 minutes of ischemia and 30 minutes of reperfusion
Comparison
ACE inhibitors infused during control, ischemic… vs Control conditions or co-administration with…
Design
Preclinical
Follow-up
150 minutes
Authors
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May attenuate ET-1-driven reperfusion arrhythmias in experimental ischemia; leaves open translation to clinical cardioprotection.
Does ACE inhibitor administration reduce ET-1 secretion and reperfusion arrhythmias in perfused rat hearts?
ACE inhibitors suppress endogenous ET-1 secretion, which improves coronary function and stabilizes cardiac rhythm after ischemia in a rat model.
Brünner et al. (1996) studied this question.
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