January 1, 1993
Effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury: an overview
Why the study?
Do ACE inhibitors reduce myocardial ischemia/reperfusion injury in experimental models?
Population
Experimental models of myocardial ischemia/reperfusion injury
Design
Review
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for experimental cardioprotection; leaves open clinical translation and infarct size effects.
Structured PICO
Do ACE inhibitors reduce myocardial ischemia/reperfusion injury in experimental models?
P
Population
Experimental models of myocardial ischemia/reperfusion injury (including isolated hearts and in vivo anesthetized dogs)
I
Intervention
Angiotensin-converting enzyme (ACE) inhibitors
O
Outcome
Myocardial ischemia/reperfusion injury (including metabolic, arrhythmic, and contractile derangements, myocardial stunning, and infarct size)surrogate
ACE inhibitors show potential in attenuating myocardial ischemia/reperfusion injury through mechanisms such as bradykinin potentiation and antioxidant activity, warranting further investigation.
Limitations
- No data available regarding the effect on myocardial stunning after a prolonged, partly reversible episode
- No data available after multiple consecutive brief ischemic episodes
- No data available after global ischemia
- Effects on myocardial infarct size remain controversial
Cite This Study
Zughaib et al. (1993) studied this question.