Why the study?
Do ACE inhibitors improve cardiac hypertrophy and contractility by decreasing afterload in experimental models of hypertension and heart failure?
Do ACE inhibitors improve cardiac hypertrophy and contractility by decreasing afterload in experimental models of hypertension and heart failure?
The beneficial effects of ACE inhibitors on cardiac hypertrophy and contractility in experimental models appear to be directly dependent on their ability to decrease afterload.
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ACE inhibitor effects on hypertrophy require BP reduction in animal models; leaves open the role of afterload reduction in patients.
Jean‐Baptiste Michel (1990) studied this question.
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