Key result
Cystatin C-estimated GFR <60 ml/min/1.73 m2 and urine ACR ≥30 mg/g were independently associated with increased mortality risk (HR 1.73; 95% CI 1.37-2.18 and HR 1.73; 95% CI 1.39-2.17, respectively).
Why the study?
Does impaired GFR and albuminuria increase mortality in older adults with diabetes?
Population
691 older adults with diabetes from the Cardiovascular Health Study, mean age 78 years
Comparison
Impaired GFR and albuminuria vs Normal GFR and normal urine ACR
Design
Cohort
Follow-up
10 years
Authors
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May enhance mortality risk stratification with cystatin C-eGFR and ACR in older diabetic adults; leaves open whether targeting these markers improves outcomes.
Cohort (n=691)
Does impaired GFR and albuminuria increase mortality in older adults with diabetes?
Effect estimate: HR 1.73 (95% CI 1.37-2.18)
Albuminuria and impaired GFR are independent, additive risk factors for mortality among older adults with diabetes, with cystatin C predicting mortality more strongly than creatinine.
Boer et al. (2009) conducted a cohort in Diabetes (n=691). Impaired GFR and albuminuria was evaluated on Mortality (HR 1.73, 95% CI 1.37-2.18). Cystatin C-estimated GFR <60 ml/min/1.73 m2 and urine ACR ≥30 mg/g were independently associated with increased mortality risk (HR 1.73; 95% CI 1.37-2.18 and HR 1.73; 95% CI 1.39-2.17, respectively).
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