Key result
Family screening of patients with surgically proved isolated bicuspid aortic valves revealed a minimum family incidence of 14.6%, suggesting multifactorial inheritance.
Population
41 patients with surgically proved isolated bicuspid aortic valves and their 188 living first-degree relatives
Design
Cross-sectional
Authors
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May support family screening in isolated BAV; leaves open inheritance patterns pending prospective confirmation.
Observational (n=229)
Bicuspid aortic valve has a significant familial incidence (14.6% to 31.7%), suggesting multifactorial or occasionally autosomal dominant inheritance, highlighting the importance of screening first-degree relatives.
Emanuel et al. (1978) conducted an observational in Congenitally bicuspid aortic valves (n=229). Family screening of patients with surgically proved isolated bicuspid aortic valves revealed a minimum family incidence of 14.6%, suggesting multifactorial inheritance.
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