Key result
In CAD patients with hypertension, pulse pressure was a weaker predictor of cardiovascular outcomes than SBP, DBP, or MAP (-2 log-likelihood difference 7.3 vs 77.1 for SBP).
Why the study?
Is pulse pressure a stronger predictor of cardiovascular outcomes than SBP, DBP, or MAP in patients with hypertension and CAD?
RCT (n=22,576)
randomized
Yes
Is pulse pressure a stronger predictor of cardiovascular outcomes than SBP, DBP, or MAP in patients with hypertension and CAD?
No takes yet. Share an insight, caveat, or question.
PP weaker than SBP for outcomes in hypertensive CAD; leaves open incremental value in risk models.
Bangalore et al. (2009) conducted an RCT in coronary artery disease (CAD) with hypertension (n=22,576). verapamil-SR based strategy vs. atenolol-based strategy was evaluated on time to first occurrence of death (all-cause), non-fatal myocardial infarction (MI), or non-fatal stroke. In CAD patients with hypertension, pulse pressure was a weaker predictor of cardiovascular outcomes than SBP, DBP, or MAP (-2 log-likelihood difference 7.3 vs 77.1 for SBP).
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