August 23, 1995JAMA
Calcium Channel Blockers and Myocardial Infarction
Key result
Calcium channel blockers prescribed for hypertension were associated with an increased risk of myocardial infarction compared to diuretics alone (RR 1.6; 95% CI 1.1-2.3).
Why the study?
Do calcium channel blockers increase the risk of myocardial infarction in hypertensive patients compared to diuretics alone?
Population
Hypertensive patients enrolled in the Group Health Cooperative of Puget Sound
Comparison
Calcium channel blockers vs Diuretics alone
Design
Editorial
Authors
Discussion
Loading...
Member takes
Implication
This editorial highlights a case-control study suggesting an increased risk of myocardial infarction among hypertensive patients treated with calcium channel blockers compared to diuretics.
Structured PICO
Do calcium channel blockers increase the risk of myocardial infarction in hypertensive patients compared to diuretics alone?
P
Population
Hypertensive patients enrolled in the Group Health Cooperative of Puget Sound
I
Intervention
Calcium channel blockers
C
Comparator
Diuretics alone
O
Outcome
Myocardial infarctionhard clinical
Main Result
Effect estimate: RR 1.6 (95% CI 1.1 to 2.3)
This editorial highlights a case-control study suggesting an increased risk of myocardial infarction among hypertensive patients treated with calcium channel blockers compared to diuretics.
Limitations
- Cannot evaluate definitively whether calcium channel blockers increase risk of myocardial infarction
- Retrospective study design
- Retrospective case-control design cannot evaluate definitively
Cite This Study
Julie E. Buring (1995) conducted an editorial in Hypertension. Calcium channel blockers vs. Diuretics alone was evaluated on Myocardial infarction (RR 1.6, 95% CI 1.1 to 2.3). Calcium channel blockers prescribed for hypertension were associated with an increased risk of myocardial infarction compared to diuretics alone (RR 1.6; 95% CI 1.1-2.3).