Why the study?
Does the use of calcium channel blockers increase the risk of myocardial infarction in hypertensive patients?
Population
96 hypertensive patients from a single hospital in Japan.
Comparison
Calcium channel blockers (CCBs) vs No calcium channel blockers
Design
Case-control
Follow-up
between 1996 and 1999
Authors
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Does not support restricting calcium channel blocker use in hypertension; leaves open confounding by indication in case-control data.
Does the use of calcium channel blockers increase the risk of myocardial infarction in hypertensive patients?
The apparent increased risk of myocardial infarction associated with calcium channel blockers in hypertensive patients is likely driven by confounding by indication rather than a true causal effect.
Ohyama et al. (2002) studied this question.
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