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January 26, 2012AnesthesiologyOpen Access

Intraoperative Hypotension and Perioperative Ischemic Stroke after General Surgery

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Key result

Intraoperative hypotension (mean blood pressure decrease >30% from baseline) was significantly associated with postoperative ischemic stroke, which occurred in 0.09% of the 48,241 surgical cohort.

Why the study?

Does intraoperative hypotension increase the risk of postoperative ischemic stroke in patients undergoing noncardiac and nonneurosurgical procedures?

Population

294 patients drawn from a cohort of 48,241 patients who underwent noncardiac and nonneurosurgical procedures.

Comparison

Intraoperative hypotension vs Matched controls without postoperative stroke

Design

Case-control

Follow-up

10 days after surgery

Authors

JBJilles B. BijkerZiekenhuis Gelderse ValleiSPSuzanne PersoonUniversity Medical Center UtrechtLPLinda M. PeelenPreventive Cardiology

Discussion

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Implication

May warrant BP monitoring caution; hypothesis-generating in case-control data and needs prospective confirmation.

Study Design

Type

Case-Control (n=294)

Structured PICO

Does intraoperative hypotension increase the risk of postoperative ischemic stroke in patients undergoing noncardiac and nonneurosurgical procedures?

P
Population
294 patients (42 stroke cases matched to 252 controls) drawn from a cohort of 48,241 patients who underwent noncardiac and nonneurosurgical procedures.
I
Intervention
Intraoperative hypotension (duration of mean blood pressure decrease >30% from baseline)
C
Comparator
Matched controls without postoperative stroke
O
Outcome
Occurrence of an ischemic stroke within 10 days after surgeryhard clinical

Intraoperative hypotension, specifically a mean blood pressure decrease of >30% from baseline, is significantly associated with an increased risk of postoperative ischemic stroke in noncardiac, nonneurosurgical procedures.

Cite This Study

Bijker et al. (2012) conducted a case-control in Patients undergoing noncardiac and nonneurosurgical procedures (n=294). Intraoperative hypotension vs. No intraoperative hypotension was evaluated on Occurrence of an ischemic stroke within 10 days after surgery. Intraoperative hypotension (mean blood pressure decrease >30% from baseline) was significantly associated with postoperative ischemic stroke, which occurred in 0.09% of the 48,241 surgical cohort.

synapsesocial.com/papers/6a145678a4182367b162bebchttps://doi.org/10.1097/aln.0b013e3182472320
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ischemic stroke after surgical procedures1998 · 173 citations
  2. 2Mechanisms of perioperative cerebral infarction.1982 · 115 citations
  3. 3Risk of Surgery and Anesthesia for Ischemic Stroke2000 · 96 citations
  4. 4Prevention and Treatment of Perioperative Stroke2008 · 28 citations
  5. 5Perioperative Strokes and β-Blockade2009 · 27 citations