Why the study?
Despite increasing use of bioprosthetic aortic valves, an ideal bioprosthesis is lacking, making understanding native heart valve biology crucial for designing better valve tissues.
Design
Literature review
Key result
Bioprosthetic valve structural dysfunction is a consequence of chemical, mechanical, and immunological processes occurring during fixation, manufacture, and implantation.
Authors
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Does not alter current valve selection; extends mechanistic insights to guide next-generation bioprosthesis development.
Understanding the basic science mechanisms of bioprosthetic aortic valve degeneration is crucial for developing more durable next-generation bioprostheses.
Velho et al. (2022) conducted a review in Bioprosthetic Aortic Valve Degeneration. Bioprosthetic valve structural dysfunction is a consequence of chemical, mechanical, and immunological processes occurring during fixation, manufacture, and implantation.