Key result
IL-10 and CRP are inversely linked to arterial stiffness in male AAA patients on metformin.
Why the study?
The roles of markers of inflammation and arterial stiffness in the mechanisms and progression of abdominal aortic aneurysm in males have not been fully investigated.
Is there an association between inflammatory markers (IL-10, CRP) and arterial stiffness in males with abdominal aortic aneurysm?
Observational (n=270)
Is there an association between inflammatory markers (IL-10, CRP) and arterial stiffness in males with abdominal aortic aneurysm?
Effect estimate: r = 0.571
p-value: p=0.036
Arterial stiffness is associated with inflammation (CRP and IL-10) in males with AAA, with a potential modifying effect of metformin in those with type 2 diabetes.
BACKGROUND: Markers of inflammation and arterial stiffness are predictors of cardiovascular morbidity and events, but their roles in the mechanisms and progression of abdominal aortic aneurysm (AAA) in males have not been fully investigated. This study explored possible associations between inflammatory marker levels and arterial stiffness in males with AAA. METHODS: A total of 270 males (191 AAA and 79 controls) were included in the study. Arterial stiffness was assessed using non-invasive applanation tonometry to measure the regional pulse wave velocity between the carotid and femoral arteries and the carotid and radial arteries. Blood samples were obtained, and interleukin-10 (IL-10) and CRP levels were analysed. RESULTS: = 0.036). We observed a positive correlation between PWVcf and CRP in the control group (r = 0.332) but not the AAA group. PWVcf and CRP were negatively correlated (r = 0.571) in the T2DM subjects treated with metformin in the AAA group. CONCLUSION: Arterial stiffness is related to the degree of inflammation reflected by CRP and IL-10 levels in males with an AAA. IL-10 is negatively correlated with arterial stiffness in these subjects. This finding suggests that IL-10 may decrease arterial stiffness in males with AAA. The negative correlation between CRP and PWVcf in males with T2DM treated with metformin may indicate that metformin influences the arterial wall to decrease stiffness in subjects with AAA.
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Malm et al. (2022) conducted an observational in Abdominal Aortic Aneurysm (n=270). IL-10 and CRP levels vs. Controls was evaluated on Correlation between inflammatory markers (IL-10, CRP) and arterial stiffness (pulse wave velocity) (r = 0.571, p=0.036). In males with abdominal aortic aneurysm, IL-10 was negatively correlated with arterial stiffness, and CRP was negatively correlated with pulse wave velocity in those treated with metformin (r=0.571).
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