Key result
Perindopril 4 mg administered at 2100 h reduced the early morning blood pressure rise more than the 0900 h dose (P=0.05-0.10), but failed to provide 24-hour blood pressure control.
Why the study?
Does perindopril 4 mg administered in the morning versus at night improve 24-hour blood pressure control in male patients with hypertension?
Population
20 male patients with diastolic blood pressure 95-110 mmHg when seated and 24 h mean ambulatory diastolic…
Comparison
Perindopril 4 mg administered at 0900 h for 4… vs Perindopril 4 mg administered at 2100 h for 4…
Design
RCT, allocated randomly
Follow-up
4 weeks per treatment period
Authors
Loading...
Nighttime perindopril marginally attenuates morning surge without 24-hour control; challenges chronotherapy assumptions and leaves optimal ACEI timing open.
RCT (n=20)
Randomized crossover
No
Does perindopril 4 mg administered in the morning versus at night improve 24-hour blood pressure control in male patients with hypertension?
p-value: p=0.05-0.10
Morning administration of perindopril provides better 24-hour blood pressure control compared to nighttime administration, highlighting the importance of chronobiology in antihypertensive therapy.
Morgan et al. (1997) conducted an RCT in Hypertension (n=20). perindopril vs. 0900 h vs 2100 h administration was evaluated on clinic and ambulatory blood pressure (p=0.05-0.10). Perindopril 4 mg administered at 2100 h reduced the early morning blood pressure rise more than the 0900 h dose (P=0.05-0.10), but failed to provide 24-hour blood pressure control.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: