Why the study?
Does perindopril reduce systolic and diastolic arterial pressure in patients with hypertension?
Population
289 patients with hypertension
Comparison
Perindopril 4 mg once daily or 2 mg twice daily… vs Placebo
Design
RCT, randomized, double-blind
Follow-up
16 weeks
Authors
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Supports perindopril for hypertension; confirms greater BP reduction versus placebo in this RCT.
Does perindopril reduce systolic and diastolic arterial pressure in patients with hypertension?
Perindopril is an effective and well-tolerated once-daily treatment for hypertension, with a dose-response curve that flattens after 8 mg per day.
Chrysant et al. (1993) studied this question.
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