Antihypertensive Utility of Perindopril in a Large, General Practice‐Based Clinical Trial
Key result
Perindopril treatment for 12 weeks reduced mean sitting blood pressure from 156.9/94.5 to 139.2/84.0 mm Hg, with 48.8% of patients achieving blood pressure control.
Why the study?
Does perindopril reduce blood pressure in US hypertensive patients?
Population
13,220 US hypertensive patients
Design
Cohort, open-label
Follow-up
12 weeks
Authors
Discussion
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Member takes
Implication
Supports perindopril for BP lowering in US patients; extends real-world cohort data but leaves open need for randomized confirmation.
Structured PICO
Does perindopril reduce blood pressure in US hypertensive patients?
P
Population
13,220 US hypertensive patients treated with perindopril and followed for 12 weeks in a community-based open-label trial.
I
Intervention
Perindopril 4 mg once daily for 6 weeks, with dose maintained at 4 mg or increased to 8 mg for an additional 6 weeks based on physician perception of blood pressure response
O
Outcome
Mean sitting blood pressure change from baseline to week 12surrogate
Perindopril effectively lowers blood pressure in a large, real-world community setting, highlighting its utility despite suboptimal physician adherence to hypertension guidelines.
Cite This Study
Julius et al. (2004) studied Hypertension (n=13,220). Perindopril was evaluated on Blood pressure control (<140/<90 mm Hg) at 12 weeks. Perindopril treatment for 12 weeks reduced mean sitting blood pressure from 156.9/94.5 to 139.2/84.0 mm Hg, with 48.8% of patients achieving blood pressure control.