Antihypertensive Utility of Perindopril in a Large, General Practice‐Based Clinical Trial
Key result
Perindopril treatment for 12 weeks significantly reduced mean sitting blood pressure from 156.9/94.5 mm Hg to 139.2/84.0 mm Hg, achieving blood pressure control in 48.8% of patients.
Why the study?
Does perindopril reduce blood pressure in US hypertensive patients?
Population
13,220 US hypertensive patients
Design
Cohort, open-label
Follow-up
12 weeks
Authors
Discussion
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Member takes
Implication
Supports perindopril in US hypertensives; extends real-world data but leaves open randomized confirmation.
Structured PICO
Does perindopril reduce blood pressure in US hypertensive patients?
P
Population
13,220 US hypertensive patients treated with perindopril and followed for 12 weeks to evaluate effectiveness and safety.
I
Intervention
Perindopril 4 mg once daily for 6 weeks, with dose maintained or increased to 8 mg for an additional 6 weeks based on physician perception of blood pressure response
O
Outcome
Mean sitting blood pressure at 12 weekssurrogate
Perindopril monotherapy effectively reduces blood pressure and is well tolerated in a large community-based cohort of US hypertensive patients.
Cite This Study
Julius et al. (2005) studied Hypertension (n=13,220). Perindopril was evaluated on Blood pressure control (<140/<90 mm Hg) at 12 weeks. Perindopril treatment for 12 weeks significantly reduced mean sitting blood pressure from 156.9/94.5 mm Hg to 139.2/84.0 mm Hg, achieving blood pressure control in 48.8% of patients.