Key result
Refining hypertension phenotypes by analyzing hemodynamic subsets in younger individuals alongside common biomarkers may decrease patient heterogeneity and improve genetic and mechanistic studies.
Refining hypertension phenotypes by hemodynamic subsets and age may improve the clarity and success of future genetic and mechanistic studies.
May guide refined phenotyping in hypertension research; leaves open any clinical practice changes pending validation.
The study of genes and mechanisms associated with hypertension is hampered by the heterogeneity of hypertensive patients. Refining the definition of hypertension is a potential means of improving the clarity of mechanistic studies, but the lack of intermediate phenotypes hinders the assessment of causal relationships. Looking at younger individuals and hemodynamic subsets of hypertension is one such refinement. The authors argue that the separate analysis of patients with isolated diastolic hypertension, predominantly diastolic hypertension, and isolated systolic hypertension in the young in combination with common biomarkers may be an initial step to decrease heterogeneity within patient subsets, thus providing new avenues for genetic and pathophysiological studies.
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Orías et al. (2010) conducted a review in Hypertension. Refining hypertension phenotypes by analyzing hemodynamic subsets in younger individuals alongside common biomarkers may decrease patient heterogeneity and improve genetic and mechanistic studies.
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