Key result
Increased sympathetic tone in hypertension is widespread, neurogenic, and may drive multiple pressure-independent coronary risk factors via down-regulation of beta-adrenergic responsiveness.
This review highlights the widespread nature of sympathetic overactivity in hypertension and proposes that down-regulation of beta-adrenergic responsiveness contributes to both haemodynamic and metabolic alterations.
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May prompt sympathetic modulation beyond BP lowering in hypertension; leaves open whether beta-adrenergic down-regulation drives independent coronary risk.
Julius et al. (2000) conducted a review in Hypertension. Sympathetic overactivity was evaluated. Increased sympathetic tone in hypertension is widespread, neurogenic, and may drive multiple pressure-independent coronary risk factors via down-regulation of beta-adrenergic responsiveness.
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