Key result
Increasing obesity severity is linked to ~8-fold higher odds of diabetes and other cardiometabolic diseases.
Why the study?
The study examined the association between obesity severity, using BMI as a surrogate, and cardiometabolic and renal disease.
Is increasing obesity severity associated with higher odds of cardiometabolic and renal disease in the US population?
Cross-Sectional
Is increasing obesity severity associated with higher odds of cardiometabolic and renal disease in the US population?
Effect estimate: OR 8.32 (95% CI 7.78-8.91)
Increasing obesity severity is strongly associated with a higher burden of cardiometabolic and renal diseases, including earlier onset of diabetes.
Association warrants vigilance in severe obesity; leaves open causal confirmation and intervention effects in longitudinal data.
OBJECTIVE: This study examined the association between obesity severity and cardiometabolic and renal disease, using BMI as a surrogate for obesity severity. METHODS: This is a cross-sectional study using data from the United States Behavioral Risk Factor Surveillance System (BRFSS), 2011-2023. Survey-weighted logistic regression estimated odds ratios (OR) for the diagnosis of diabetes, hypertension, hyperlipidemia, kidney disease, myocardial infarction, stroke, and coronary artery disease among increasing BMI categories. RESULTS: , odds were notably elevated for diabetes (OR 8.32; 95% CI: 7.78-8.91), hypertension (OR 6.07; 95% CI: 5.58-6.61), and kidney disease (OR 3.60; 95% CI: 3.21-4.03). The odds of cardiovascular disease also rose substantially, including myocardial infarction (OR 2.89; 95% CI: 2.56-3.28) and coronary artery disease (OR 3.44; 95% CI: 3.08-3.84). Mean age at diabetes diagnosis decreased with increasing BMI, from 52.2 years in Class I to 45.3 years in Class IV obesity. CONCLUSIONS: . These findings highlight the urgent need for early, aggressive interventions targeting individuals with all classes of obesity.
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Corpodean et al. (2025) conducted a cross-sectional in Obesity. Increasing BMI categories vs. Lower BMI categories was evaluated on Diagnosis of diabetes (OR 8.32, 95% CI 7.78-8.91). Increasing obesity severity was associated with substantially elevated odds of cardiometabolic and renal diseases, including diabetes (OR 8.32; 95% CI 7.78-8.91) and hypertension.
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