Key result
Targeting of PABP by both RNA and DNA viruses alters its stability, complex formation, and intracellular localization, highlighting its role as a central regulator of gene expression.
Design
Review
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Viral hijacking of PABP may guide future host-directed antivirals; leaves open validation in cardiovascular infection models.
PABP serves as a central regulator of gene expression that is targeted by both RNA and DNA viruses during infection.
Smith et al. (2010) conducted a review in Viral infection. PABP targeting by viruses was evaluated. Targeting of PABP by both RNA and DNA viruses alters its stability, complex formation, and intracellular localization, highlighting its role as a central regulator of gene expression.
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